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The vitamins regulate body functions and significantly increase the resistance against illnesses and stress. The fact that it contains many vitamins from the B group has a positive impact on the nervous system. The vitamin A contains contributes to the well-being of the eyes, the skin, the hair and the nails.

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The sea-buckthorn Eubias™ Hippophaes Eubias™) is also very rich in vitamin E and contributes to the improvement of both the spiritual and the physical performance of our body.

Power and well-being…with minerals and trace elements 
The sea-buckthorn Eubias™ (Hippophaes Eubias™) is one of the most complete nutritional supplements that have been discovered until nowadays because the vitamins and the minerals contains are perfectly balanced and can be taken at the same time. Unlike some vitamins and minerals that may have side effects when taken in a wrong way or without a medical prescription, the sea-buckthorn Eubias™ (Hippophaes Eubias™) is completely safe.

Invigoration…with fatty acid
The sea-buckthorn Eubias™ (Hippophaes Eubias™) has the highest level of vegetable fatty acids that has been discovered until nowadays and as a result, it provides the human body with systematic invigoration and energy. According to researches, the lack of fatty acids in people’s nutrition is related to the inadequate function of many systems of our organism such as the cardiovascular, the nervous and the immune system.
The sea-buckthorn Eubias™ (Hippophaes Eubias™) is proved to be the best source of Omega-3, Omega-6, Omega-7 and Omega-9 fatty acids for our organism. It contributes to the correct function of hormones, to the regulation of blood pressure and to the reduction in the levels of “bad” cholesterol.

Antioxidant activity…with lycopene, carotene, flavonoids
The sea-buckthorn Eubias™ (Hippophaes Eubias™) is regarded as one of the best foods as far as its levels of antioxidant elements are concerned.
It is exceptionally rich in lycopene, zeaxanthin and flavonoids and it is the only food that contains more than 15 powerful substances that are valuable for the human body.
As a result, it is obvious that it contributes to the elimination of free radicals which are responsible for many different types of cancer.

Recent scientific studies outcomes 
Hippophae rhamnoides is one of the oldest land plants, dated back to the ice age. First reports referring to its therapeutic effects appear in the 4th century B.C. According to historical sources, Hippophae was part of Alexander the Great soldiers’ diet. It was observed that sick and injured horses were healed by leaves and fruit of this plant. References of its use as drug are also found in classical Tibetan and Chinese medicine; other sources report that in the 13th century Jenkins Khan had been using it in his campaigns. It was not until 1929 that the first biochemical analysis of Hippophae fruits took place, and since then, our knowledge of its medicinal properties is increasing. Nowadays, Hippophae is one of the most prestigious plants of modern alternative medicine.

Hippophae rhamnoides, also known as sea buckthorn, is a member of the Elaeagnaceae family. It germinates as wild large shrub in Eurasia; oil of its fruits is extracted by crushing, no chemicals added. According to biochemical analysis made, Hippophae oil contains more than 190 nutrients and organic substances. The Astra Medical Hellas company disposes the nutritional supplement named Hippophae Eubias™, containing 350 mg Hippophae ramnoides oil extract/ capsule (TD No 75-09). It is also available in powder form (TD No 59-09).

Active compounds
Hippophae rhamnoides contains vitamin C, alpha-tocopherol, large amount of carotenoids and vitamin E, mineral elements (K, Na, Mg, Ca, Fe, Zn, Se), monosaccharides sugars, organic acids, free amino-acids, volatile compounds, various flavonoids (quercetin, myricetin and kaempferol), fatty acids, triacylglycerol, glycerolphospholipids, phytosterols, zeaxanthin esters, and phelonic compounds. Due to its compounds, H. rhamnoides manifests various beneficial actions: antioxidant, anti-inflammatory, antimicrobial, antitumoral, hepato-protective, and immuno-modulatory.

Antioxidant effect
Various in vitro and in vivo studies clearly demonstrate that H. rhamnoides L. has antioxidant activity. The leaf extract of this plant protects significantly male albino rats from chromium induced oxidative injury. Hexane extract of H. rhamnoides L. fruits has shown to inhibit nicotine-induced oxidative stress in rat erythrocytes. However, it could not prevent nicotine-induced oxidative stress in the brain of these rats, probably because it could not have been diffused to the rat brain, so as to exert its antioxidant effect. Hexane extract of H. rhamnoides L. has also prevented the depletion of the most abundant thiol, glutathione, in gastric tissue of ethanol-administered rats.

Immunomodulatory effects
The leaf extract of sea buckthorn has significant immunomodulatory activity and specifically activates the cell-mediated immune response. In chromium-induced immuno-suppressed animals, the leaf extract of sea buckthorn significantly inhibited chromium-induced reactive oxygen species (ROS) generation and maintained the cell size identical to that of control cells. In addition, the leaf extract (100 μg/ ml) alone, stimulated IL-2 and γ-IFN production, and also inhibited chromium-induced decline in IL-2 and γ-IFN production; however, it did not change IL-4 production.

Cardiovascular disease
H. rhamnoeides is used as anti-cardiovascular medicine. The supplementation of H. rhamnoides L. juice (with vitamin C, alpha-tocopherol, beta-carotene and flavonoids) increased plasma HDL-cholesterol and triacylglycerol concentrations by 20% and 17%, respectively, in healthy male volunteers. In addition, supplementation resulted in a moderate decrease in the susceptibility of LDL-C to oxidation in these subjects.
Total flavones of H. rhamnoides L. fruit have prolonged thrombotic occlusion time in a mouse femoral artery thrombosis model by the photochemical reaction between intravenously injected rose bengal and green light irradiation. In the same study, total flavones have inhibited in vitro platelet aggregation induced by collagen, in a concentration dependent manner. In an animal study, the flavonoids of sea buckthorn were shown to reduce the production of pathogenic thromboses in mice. In addition, total flavones (100 mg/L) decreased in vitro the duration of repolarisation period in both cultured rat myocardial cells and guinea pig papillary muscles; thus they contribute in better myocardial function.

Hippophae alcohol extract containing mainly flavonoids is reported to protect bone marrow from damage due to radiation; it might also help bone marrow cells recover faster. In an animal model, mice fed with sea buckthorn oil, had their hemopoietic system recovered faster after high dose chemotherapy. Antitumor effects of fruit juice and seed oil, and prevention of aminopyrine-induced tumour production in rats, by juice of H. rhamnoides L., have been reported.

Antimicrobial effects
A few studies show that H. rhamnoides L. has antimicrobial effects. Phenolic compounds of H. rhamnoides L. berry inhibit the growth of Gram-negative bacteria.

Antiulcerogenic effect
Curative and preventive effects of H. rhamnoides L. against experimental gastric ulcers in rats have been reported by various studies. Hexane extract from H. rhamnoides fruits have demonstrated antiulcerogenic effects on indomethacin- and stress-induced ulcer models, and on ethanol-induced gastric lesion. Acceleration of healing process of acetic acid-induced gastric ulcer, by oils of CO2- extract from the seeds and pulp of Hippophae rhamnoides L., has also been reported.

Dermatological effects
Beneficial effect of H. rhamnoides L. in dermatological disorders is known. Of the 4 months oral supplementation of pulp and seed oils in patients with atopic dermatitis, improvement in dermatitis was followed only in pulp oil supplemented group.

Effects on liver injury
Clinical effects of H. rhamnoides L. oil on liver fibrosis have also been tested recently. The oil treatment has also notably shortened the duration for normalization of aminotransferases. The results suggest that seed oil of H. rhamnoides L. may also be a useful for prevention and treatment of liver diseases.

Radioprotective effects
Protection against whole body lethal irradiation by whole berries of H. rhamnoides L., has been reported in mice. Goel et al. have demonstrated on mice that alcoholic extract have rendered 82% survival as compared to no survival in irradiated control. As proved, this extract had induced a strong compaction of chromatin, as was evident from lack of tail and appearance of intensely stained circular bodies (in Comet assay single cell gel electrophoresis). This could have made the nuclei resistant even to a radiation dose of 1000 Gy. The alcoholic extract has also inhibited radiation-induced and tertiary butyl hydro peroxide (TBHP)-induced DNA strand breaks, in a dose dependent manner. The ability of this alcoholic extract of H. rhamnoides L. to protect DNA could mainly be attributed to direct modulation of chromatin.

Who are to take it
According to the above, Hippophae Eubias™ can be used to protect our body from smoking and stress injury, to enhance mental and physical performance, to improve skin/ hair/ nail appearance and to ameliorate chronic disease symptoms (e.g. joint pain, depression, hypertension etc).

Unlike some vitamins/ minerals which can manifest side effects if administered incorrectly or without a prescription, Hippophae Eubias™ is absolutely safe. For optimal absorption take it with food (1-2 caps per day). Keep out of the refrigerator up to 25°C.

The sea-buckthorn Eubias™ (Hippophaes Eubias™)
It contains 30 soft capsules at the proposed price of 22,31 Euros. For better absorption it should be taken with food. It can be preserved outside the fridge when the temperature is up to 25o C. The dosage frequency is indicated on the package. Available in pharmacies.

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It is considered as one of the richest natural sources of nutrients because it is very rich in b-carotene, vitamin C, vitamins B1 and B2 and in a series of other vitamins, carbohydrates, proteins, fatty acids, nutritional fibers, mineral elements, antioxidant substances and amino acids, all of which are essential to the body.